Artigos
OLIVEIRA, GABRIELA P. ; LIMA, MAURO A. ; PEREIRA, GEORGE B.S. ; COSTA, ANALU R. ; BATISTA, ALZIR A. ; FORIM, MOACIR R. ; Cominetti, Marcia R. ; ZANETTI, RENAN D. ; FARIAS, RENAN L. ; NETTO, ADELINO V.G. ; ARAUJO-NETO, JOÃO H. ; ELLENA, JAVIER A. ; OLMEDO-MORENO, LAURA ; CAPILLA-GONZALEZ, VIVIAN ; ROCHA, FILLIPE V. . Palladium(II) and platinum(II) thiophene-based thiosemicarbazones: Synthesis, properties, and anticancer studies. JOURNAL OF MOLECULAR STRUCTURE, v. 1322, p. 140306, 2025
TARGAS, ANA BEATRIZ APARECIDA ; VICTORIANO, PEDRO HENRIQUE MOREIRA ; GARCIA, MATEUS BALLEIRO BERTOLDO ; ALEXANDRE-SILVA, VANESSA ; COMINETTI, MARCIA REGINA . Exploring the connection between dementia and cardiovascular risk with a focus on ADAM10. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, v. 1872, p. 167825, 2025
DE CARVALLHO PELEGRINI, LUCAS NOGUEIRA ; MANZINE, PATRICIA REGINA ; POPOLIN, CECILIA PATRICIA ; DORTA, SABRINA ; GRIGOLI, MARINA MANTELLATTO ; ALEXANDRE-SILVA, VANESSA ; PEDROSO, RENATA ; RAMOS, ARI ALEX ; POTT-JR, HENRIQUE ; COMINETTI, MARCIA REGINA . Higher soluble ADAM10 plasma levels are associated with decreased cognitive performance in older adults carrying APOEε4. NEUROBIOLOGY OF AGING, v. 152, p. 1, 2025
PELEGRINI, LUCAS NOGUEIRA DE CARVALHO ; BACKHOUSE, TAMARA ; GRATÃO, ALINE CRISTINA MARTINS ; COMINETTI, MARCIA REGINA . Frequency of care mediates the effect of older adults? cognitive performance on the perceived strain of their informal caregivers in a middle-income country. Dementia-International Journal of Social Research and Practice, v. x, p. x, 2025
GRAMINHA, ANGELICA E. ; BECCENERI, AMANDA B. ; RIOS, RAFFAELA ; Cominetti, Márcia Regina ; BIAZZOTTO, JULIANA CRISTINA ; SANTANA DA SILVA, ROBERTO . Antagonistic effect of a nitric oxide donor agents based on ruthenium complex combined with cisplatin on lung tumor cell lines. NITRIC OXIDE-BIOLOGY AND CHEMISTRY, v. 1089, p. 1, 2025
ZUTIÃO, ARTHUR DEPONTE ; PACHANE, BIANCA CRUZ ; NUNES, PAULO SÉRGIO GONÇALVES ; VIDAL, HERIKA DANIELLE ALMEIDA ; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO ; CORRÊA, ARLENE GONÇALVES ; COMINETTI, MARCIA REGINA ; FUZER, ANGELINA MARIA . Enhanced Cytotoxicity of [10]-Gingerol-Coumarin-Triazole Hybrid as a Theranostic Agent for Triple Negative Breast Cancer. ACS Medicinal Chemistry Letters, v. 16, p. 436-443, 2025
PALMA, LETICIA FERNANDA ; BOM, REBECA CARVALHO ; PULGATTI, KAREN LETICIA ; ALEXANDRE-SILVA, VANESSA ; BOMFIM, ANA JULIA DE LIMA ; COMINETTI, MARCIA REGINA ; PELEGRINI, LUCAS NOGUEIRA DE CARVALHO . Factors influencing the cognitive performance in cognitively unimpaired older adults and people living with Alzheimer?s disease: Insights from a middle-income Latin American country. Applied Neuropsychology-Adult, v. 33, p. 1-11, 2025
FRASSÃO, KAUÊ O. ; FILHO, SANDRO M. S. ; PEDROSO, RENATA VALLE ; CRISPIM NASCIMENTO, CARLA M. ; POTT, HENRIQUE ; COMINETTI, MARCIA REGINA ; FRAGA, FRANCISCO J. . Classification of Apolipoprotein E -4 Allele Carriers in Cognitively Healthy Older Adults and Alzheimer's Disease Patients Using Event-Related Potentials and Event-Related Spectral Perturbation. IEEE Access, v. x, p. 1-1, 2025
BARROSO DE SOUSA, DANILO ; CLARA RIBEIRO ZUCATO, HELOISA MARIA ; RIBEIRO, HELOÍSA MÁXIMO ; ALEXANDRE-SILVA, VANESSA ; COMINETTI, MARCIA REGINA . Interplay between depressive symptoms and Alzheimer?s disease dementia: unraveling the potential roles of ADAM10 and Negr1. NEUROSCIENCE, v. 584, p. 60-64, 2025
DE OLIVEIRA, TÁSSIA R. ; MANZINE, PATRICIA R. ; Cominetti, Márcia R. ; LEITE, OLDAIR D. ; FARIA, RONALDO C. . Electrochemical magneto-immunoassay for detection of ADAM10 Alzheimer's biomarker using gold nanoparticles as label. TALANTA, v. 266, p. 125042, 2024
MANTELLATTO GRIGOLI, MARINA ; PELEGRINI, LUCAS N.C. ; WHELAN, ROBERT ; Cominetti, Marcia R. . Present and future of Blood-Based biomarkers of Alzheimer?s Disease: Beyond the classics. BRAIN RESEARCH, v. 1830, p. 148812, 2024
ALEXANDRE-SILVA, VANESSA ; COMINETTI, MARCIA REGINA . Unraveling the Dual Role of ADAM10: Bridging the Gap between Cancer and Alzheimer?s Disease. MECHANISMS OF AGEING AND DEVELOPMENT, v. 219, p. 111928, 2024
DE OLIVEIRA, SABRINA DORTA ; ALEXANDRE-SILVA, VANESSA ; POPOLIN, CECILIA PATRICIA ; DE SOUSA, DANILO BARROSO ; GRIGOLI, MARINA MANTELLATTO ; DE CARVALHO PELEGRINI, LUCAS NOGUEIRA ; MANZINE, PATRICIA REGINA ; ESPUNY, ANTONI CAMINS ; MARCELLO, ELENA ; ENDRES, KRISTINA ; COMINETTI, MARCIA REGINA . ADAM10 isoforms: optimizing usage of antibodies based on protein regulation, structural features, biological activity and clinical relevance to Alzheimer?s disease. AGEING RESEARCH REVIEWS, v. 1, p. 102464, 2024
PELEGRINI, LUCAS NOGUEIRA DE CARVALHO ; DA SILVA, VANESSA ALEXANDRE ; GRIGOLI, MARINA MANTELLATO ; VATANABE, IZABELA PEREIRA ; MANZINE, PATRICIA REGINA ; COMINETTI, MARCIA REGINA . Plasma ADAM10 Levels and their Association with Alzheimer?s Disease Diagnosis in Older Adults with Fewer Years of Formal Education. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, v. 53, p. 153-161, 2024
BECCENERI, AMANDA BLANQUE ; MARTIN, MATHEUS TORELLI ; GRAMINHA, ANGELICA ELLEN ; Cominetti, Márcia Regina ; FORD, PETER C. ; SANTANA DA SILVA, ROBERTO . The effect of light irradiation on a nitro-ruthenium porphyrin complex in the induced death of lung cancer cells in two- and three-dimensional cultures: Insights into the effect of nitric oxide. DALTON TRANSACTIONS, v. 53, p. 11264-11275, 2024
DUTRA, JOCELY L. ; HONORATO, JOÃO ; GRAMINHA, ANGÉLICA ; MORAES, CARLOS ANDRÉ F. ; DE OLIVEIRA, KLEBER T. ; Cominetti, Marcia R. ; CASTELLANO, EDUARDO E. ; BATISTA, ALZIR A. . Pd(ii)/diphosphine/curcumin complexes as potential anticancer agents. DALTON TRANSACTIONS, v. x, p. x, 2024
BECCENERI, AMANDA BLANQUE ; FUZER, ANGELINA MARIA ; LOPES, ANA CAROLINA ; DA SILVA, PATRÍCIA BENTO ; PLUTIN, ANA MARIA ; BATISTA, ALZIR AZEVEDO ; CHORILLI, MARLUS ; Cominetti, Márcia Regina . Nanoencapsulation of Ruthenium Complex Ru(ThySMet): A Strategy toImprove Selective Cytotoxicity against Breast Tumor Cells in 2D and 3DCulture Models. CURRENT DRUG DISCOVERY TECHNOLOGIES, v. 21, p. e060623217687, 2024
GARROTE, BEATRIZ L. ; LOPES, LAIS C. ; Cominetti, Márcia R. ; FARIA, RONALDO C. ; BUENO, PAULO R. . Label-free ADAM10 capacitive assay for the early diagnosis of Alzheimers disease. SENSORS AND ACTUATORS B-CHEMICAL, v. 428, p. 137208, 2024
PALMEIRA-MELLO, MARCOS V. ; TEIXEIRA, TAMARA ; DE MELO, MATHEUS REIS SANTOS ; NICOLELLA, HELOIZA DINIZ ; DUTRA, JOCELY L. ; Cominetti, Marcia R. ; ROCHA, FILLIPE VIEIRA ; TAVARES, DENISE CRISPIM ; BATISTA, ALZIR A. . Ruthenium(II)-mercapto complexes induce cell damage via apoptosis pathway on ovarian cancer cells. JOURNAL OF INORGANIC BIOCHEMISTRY, v. 264, p. 112819, 2024
GRAWE, GREGORY F. ; OLIVEIRA, KATIA M. ; LEITE, CELISNOLIA M. ; DE OLIVEIRA, TAMIRES D. ; COSTA, ANALU R. ; MORAES, CARLOS A.F. ; HONORATO, JOÃO ; Cominetti, Marcia R. ; CASTELLANO, EDUARDO E. ; CORREA, RODRIGO S. ; MACHADO, SÉRGIO P. ; BATISTA, ALZIR A. . Cytotoxic activity of Ru(II)/DPEPhos/N,S-mercapto complexes (DPEPhos -[(2-diphenylphosphino)phenyl]ether). JOURNAL OF INORGANIC BIOCHEMISTRY, v. 244, p. 112204, 2023
Izabela Pereira Vatanabe, Renata Valle Pedroso, Ramon Handerson Gomes Teles, Julio Cesar Ribeiro, Patricia Regina Manzine, Henrique Pott-Junior & Marcia Regina Cominetti (2021): A systematic review and meta-analysis on cognitive frailty in community-dwelling older adults: risk and associated factors, Aging & Mental Health, DOI: 10.1080/13607863.2021.1884844;
MONTEIRO, MPOA; OLIVEIRA, DSMO; MANZINE, PR; NASCIMENTO CMC; ORLANDI, AAS; GOMES, GAO; ORLANDI, FS; ZAZZETTA, MS; POTT-JR, H; COMINETTI, MR. ADAM10 plasma levels predict worsening in cognition of older adults: a 3-year follow-up study. Alzheimers Research & Therapy, v. 13, p. 1-8, 2021.
GRAMINHA, AE; HONORATO, J; CORREA, RS; COMINETTI MR; MENEZES, ACS; BATISTA, AA. A novel ruthenium( ii ) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells. DALTON TRANSACTIONS, v. 50, p. 323-335, 2021.
VANATABE, IP; PERON, RC; GRIGOLI, MM; PELUCCHI, S; DE CESARE, G; MAGALHÃES, T; MANZINE, PR; BALTHAZAR, MLF; DI LUCA, M; MARCELLO, E; COMINETTI, MR. ADAM10 Plasma and CSF Levels Are Increased in Mild Alzheimer's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, p. 2416, 2021.
VATANABE, IP; PEDROSO, RV; MANZINE, PR; CHAGAS, MHN; FABRÍCIO, DM; GRIGOLI, MM; NAVES MA; POTT-JR, H; COMINETTI, MR. ADAM10 as a biomarker of mild cognitive impairment but not of cognitive frailty. EXPERIMENTAL GERONTOLOGY, v. 149, p. 111303, 2021.
LUPORINI, RL; RODOLPHO, JM; KUBOTA, LT; MARTIN, ACBM; COMINETTI MR; ANIBAL, FF; POTT-JR, H. IL-6 and IL-10 are associated with disease severity and a higher comorbidity in adults with COVID-19. CYTOKINE, v. 143, p. 155507, 2021.
VELOSO, VS; OLIVEIRA, RMM; LEITE, CM; COMINETTI, MR; BARBOSA, IMM; SILVA, FLS; FEITOSA, NM; SCHULTZ, MS; BATISTA, AA . Scavenging Capacity and Cytotoxicity of New Ru(II)-diphosphine/α-amino acid complexes. POLYHEDRON, v. 202, p. 115169, 2021.
KLIONSKY, D. ET AL.; Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, v. 17, p. 1-382, 2021.
ZANESCO, IF; SILVA, ACL; DA SILVA, PB; DUARTE, JL; DI FILIPPO, LLD; CHORILLI, M; COMINETTI, MR; MARTIN, ACBM. [10]-Gingerol-Loaded Nanoemulsion and its Biological Effects on Triple-Negative Breast Cancer Cells. AAPS PHARMSCITECH, v. 22, p. 157, 2021.
LUNA-DULCEY, L; SILVA, JA; JIMENEZ-RENARD, V ; CALEIRAS, E; MOURON, S; QUINTELA-FANDINO, M; COMINETTI MR. [6]-Gingerol-Derived Semi-Synthetic Compound SSi6 Inhibits Tumor Growth and Metastatic Dissemination in Triple-Negative Breast Cancer Xenograft Models. Cancers, v. 13, p. 2855, 2021.
10. TEDESCHI, DV; DA CUNHA, AF; COMINETTI, MR; PEDROSO, RV. Efficacy of gene therapy to restore cognition in Alzheimer?s disease: a systematic review. CURRENT GENE THERAPY, v. 21, p. 246-257, 2021.
11. RIBEIRO, JC; DUARTE, JJG; GOMES, GGAO; COSTA-GUARISCO, LP; DE JESUS, ITM; NASCIMENTO, CMC; SANTOS-ORLANDI, AA; ORLANDI, FS; VASILCEAC, FA; ZAZZETTA, M; POTT-JR, H; COMINETTI, MR. Associations between inflammatory markers and muscle strength in older adults according to the presence or absence of obesity. EXPERIMENTAL GERONTOLOGY, v. 151, p. 111409, 2021.
PEDROSO, RV; FRAGA, FJ; PAVARINI, SCI; NASCIMENTO, CMC; AYÁN, C; COMINETTI, MR. A Systematic Review of Altered P300 Event-Related Potential in Apolipoprotein E4 ( APOE4 ) Carriers. CLINICAL EEG AND NEUROSCIENCE, v. 52, p. 193-200, 2021.
POTT-JR, H; COMIINETTI, MR. Comorbidities predict 30-day hospital mortality of older adults with COVID-19. GERIATRIC NURSING, v. 42, p. 1024-1028, 2021.
POTT-JR, H; BITTENCOURT, NQP; CHACHA, SFG; LUPORINI, RL; COMINETTI, MR; ANIBAL, FF. Elevations in Liver Transaminases in COVID-19: (How) Are They Related?. FRONTIERS IN MEDICINE, v. 8, p. 1-6, 2021.
VATANABE, IP; PEDROSO, RV; TELES, RHG; RIBEIRO, JC; MANZINE, PR; POTT-JR, H; COMINETTI, MR. A systematic review and meta-analysis on cognitive frailty in community-dwelling older adults: risk and associated factors. AGING & MENTAL HEALTH, v. n/a, p. 1-13, 2021.