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  • Artigos científicos últimos 5 anos
  • MANZINE, PATRICIA REGINA ; ETTCHETO, MIREN ; CANO, AMANDA ; BUSQUETS, ORIOL ; MARCELLO, ELENA ; PELUCCHI, SILVIA ; DI LUCA, MONICA ; ENDRES, KRISTINA ; OLLOQUEQUI, JORDI ; CAMINS, ANTONI ; Cominetti, Márcia Regina . ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker. BIOMEDICINE & PHARMACOTHERAPY, v. 113, p. 108661, 2019.
  • RIBEIRO, GABRIEL H. ; VEGAS, LEGNA C. ; CLAVIJO, JUAN C.T. ; ELLENA, JAVIER ; Cominetti, Marcia R. ; BATISTA, ALZIR A. . Ru(II)/N-N/PPh3 complexes as potential anticancer agents against MDA-MB-231 cancer cells (N-N-=-diimine or diamine). JOURNAL OF INORGANIC BIOCHEMISTRY, v. 193, p. 70-83, 2019.
  • COMINETTI, M. R.; ALTEI, W. F. ; SELISTRE-DE-ARAUJO, H. S. . Metastasis inhibition in breast cancer by targeting cancer cell extravasation' accepted for publication in the journal 'Breast Cancer: Targets and Therapy. Breast Cancer: Targets and Therapy, v. 11, p. 165-178, 2019.
  • NAVES, MARINA A. ; GRAMINHA, ANGELICA E. ; VEGAS, LEGNA C. ; LUNA-DULCEY, LIANY ; HONORATO, JOÃO ; MENEZES, ANTÔNIO C. S. ; BATISTA, ALZIR A. ; Cominetti, Marcia R. . Transport of the Ruthenium Complex [Ru(GA)(dppe) 2 ]PF 6 into Triple-Negative Breast Cancer Cells Is Facilitated by Transferrin Receptors. MOLECULAR PHARMACEUTICS, v. 16, p. 1167-1183, 2019.5.
  • ULIANA, CAROLINA V. ; DE OLIVEIRA, TÁSSIA R. ; Cominetti, Márcia R. ; FARIA, RONALDO C. . Label-free evaluation of small-molecule-protein interaction using magnetic capture and electrochemical detection. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 411, p. 2111, 2019.6.
  • GIMENES, LEILA ; BATISTA JUNIOR, JOAO MARCOS ; MARTINS DOS SANTOS JUNIOR, FERNANDO ; DA SILVA SOUZA, MATHEUS ; LUNA-DULCEY, LIANY ; ELLENA, JAVIER ESTEVES ; COMINETTI, MARCIA REGINA ; FATIMA DAS GRAÇAS FERNANDES DA SILVA, MARIA ; VIEIRA, PAULO CEZAR ; FERNANDES, JOAO BATISTA ; STAERK, DAN . Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana. PHYTOCHEMISTRY, v. 163, p. 38-45, 2019.
  • PERON, R. ; VATANABE, I. P. ; MANZINE, PATRICIA R. ; CAMINS, A. ; Cominetti, Marcia R. . Alpha-secretase ADAM10 regulation: insights into Alzheimer's disease treatment. PHARMACEUTICALS, v. 11, p. 1, 2018.
  • TELES, R. H. G. ; MORALLES, H. F. ; COMINETTI, M. R. . Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis. International Journal of Nanomedicine, v. Volume 13, p. 2321-2336, 2018.
  • NEVES, L. M. G. ; PARIZOTTO, N. A. ; Cominetti, Márcia R. ; BAYAT, A. . Photobiomodulation of a flowable matrix in a human skin model demonstrates energy-based enhancement of engraftment integration and remodeling. Journal of Biophotonics, v. 77, p. e201800077, 2018.
  • BECCENERI, A. B. ; POPOLIN, C. P. ; PLUTIN, A. M. ; MAISTRO, E. L. ; CASTELLANO, E E ; BATISTA, A. A. ; COMINETTI, M. R. . The trans-[Ru(PPh3)2(N,N-dimethyl-N′-thiophenylthioureato-k2O,S)(bipy)]PF6 complex has pro-apoptotic effects on triple negative breast cancer cells and presents low toxicity in vivo. JOURNAL OF INORGANIC BIOCHEMISTRY, v. 186, p. 70-84, 2018.11.
  • CUNHA, BEATRIZ N. ; COLINA-VEGAS, LEGNA ; PLUTIN, ANA M. ; SILVEIRA, RAFAEL G. ; HONORATO, JOÃO ; DE OLIVEIRA, KATIA M. ; Cominetti, Marcia R. ; FERREIRA, ANTÔNIO G. ; CASTELLANO, EDUARDO E. ; BATISTA, ALZIR A. . Hydrolysis reaction promotes changes in coordination mode of Ru(II)/acylthiourea organometallic complexes with cytotoxicity against human lung tumor cell lines. JOURNAL OF INORGANIC BIOCHEMISTRY, v. 186, p. 147-156, 2018.
  • DE SOUZA ORLANDI, FABIANA ; BROCHINE LANZOTTI, R. ; GOMES DUARTE, J. ; NOVAIS MANSUR, H. ; ZAZZETTA, M. S. ; IOST PAVARINI, S. C. ; COMINETTI, M. R. ; MATUMOTO, S. . Translation, Adaptation and Validation of Rapid Geriatric Assessment to the Brazilian Context. Journal of Nutrition Health & Aging, v. 1, p. 1-7, 2018.
  • DULCEY, L. J. L. ; TOMASIN, R. ; NAVES, M. A. ; SILVA, J. A. ; COMINETTI, M. R. . Autophagy-dependent apoptosis is triggered by a semi-synthetic [6]-gingerol analogue in triple negative breast cancer cells. Oncotarget, v. 9, p. 30787-30804, 2018.
  • FUZER, ANGELINA M. ; MARTIN, ANA CAROLINA B. M. ; BECCENERI, AMANDA B. ; DA SILVA, JAMES A. ; VIEIRA, PAULO C. ; Cominetti, Marcia R. . 10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDA-MB-231 Breast Tumor Cells. Anti-Cancer Agents in Medicinal Chemistry, v. 18, p. 1, 2018.
  • NASCIMENTO, CARLA M. C. ; ZAZZETTA, MARISA S. ; GOMES, GRACE A. O. ; ORLANDI, FABIANA S. ; GRAMANI-SAY, KARINA ; VASILCEAC, FERNANDO A. ; GRATÃO, ALINE C. M. ; PAVARINI, SOFIA C. I. ; Cominetti, Marcia R. . Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults. BMC Geriatrics, v. 18, p. 268, 2018.
  • COLINA-VEGAS, LEGNA ; OLIVEIRA, KATIA ; CUNHA, BEATRIZ ; COMINETTI, MARCIA ; NAVARRO, MARIBEL ; AZEVEDO BATISTA, ALZIR . Anti-Proliferative and Anti-Migration Activity of Arene-Ruthenium(II) Complexes with Azole Therapeutic Agents. Inorganics, v. 6, p. 132, 2018.
  • DE CAMARGO, MARIANA S. ; DE GRANDIS, RONE A. ; DA SILVA, MONIZE M. ; DA SILVA, PATRICIA B. ; SANTONI, MARIANA M. ; EISMANN, CARLOS E. ; MENEGÁRIO, AMAURI A. ; Cominetti, Marcia R. ; ZANELLI, CLESLEI F. ; PAVAN, FERNANDO R. ; BATISTA, ALZIR A. . Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors. BIOMETALS, v. 31, p. 89-100, 2018.
  • NASCIMENTO, C.M. ; INGLES, M. ; SALVADOR-PASCUAL, A. ; COMINETTI, M.R. ; GOMEZ-CABRERA, M.C. ; VIÑA, J. . Sarcopenia, frailty and their prevention by exercise. FREE RADICAL BIOLOGY AND MEDICINE, v. 20, p. 132-142, 2018.
  • MARTIN ACBM, FUZER AM, BECCENERI AB, SILVA JA, TOMASIN R, DENOYER D, KIM SH, McINTRE KA, PEARSON HB, YEO B, NAGPAL A, LING X, SELISTRE-DE-ARAUJO HS, VIEIRA PC, COMINETTI MR, POULIOT N. [10]-gingerol induces apoptosis and inhibits metastatic dissemination of triple negative breast cancer in vivo. Oncotarget, 2017 Aug 10;8(42):72260-72271.
  • MANZINE PR, PELUCCHI S, HORST MA, VALE FAC, PAVARINI SCI, AUDANO M, MITRO N, DILUCA M, MARCELLO E, COMINETTI MR. microRNA 221 Targets ADAM10 mRNA and is Downregulated in Alzheimer's Disease. J Alzheimers Dis. 2017 Oct 7. doi: 10.3233/JAD-170592.

  •  ZAZZETTA MS, GOMES GAO, ORLANDI FS, GRATAO ACM, VASILCEAC FA, GRAMANI-SAY K, PONTI MA, CASTRO PC, PAVARINI SCI, MENEZES AL, NASCIMENTO CMC, COMINETTI MR. Identifying frailty levels and associated factors in a population living in the context of poverty and social vulnerability. The Journal of Frailty and Aging, v. 6, p. 29-32, 2017.

  • BAROLLI JP, MAIA PIS, COLINA-VEGAS L, MOREIRA J, PLUTIN AM, MOCELO R, DEFLON VM, COMINETTI MR, CAMARGO-MATHIAS MI, BATISTA AA. Heteroleptic tris-chelate Ruthenium(II) complexes of N,N-disubstituted-N?-acylthioureas: synthesis, structural studies, cytotoxic activity and confocal microscopy studies. Polyhedron, v. 126, p. 33-41, 2017.
  • BAROLLI JP, CORRÊA R, MIRANDA F, RIBEIRO JU, BLOCH JRC, ELLENA J, MORENO V, COMINETTI MR, BATISTA AA. Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor. Journal of the Brazilian Chemical Society (Impresso), v. 1, p. 1-11, 2017.
  • MARTIN ACBM, TOMASIN R, BECCENERI AB, FUZER AM, VIEIRA PC, COMINETTI MR. Abstract B40: [10]-gingerol as a pro-apoptotic molecule in triple negative breast cancer. Molecular Cancer Research, v. 15, p. B40-B40, 2017.
  • FUZER AM, LEE S-Y, MOTT JD. COMINETTI MR. [10]-Gingerol Reverts Malignant Phenotype of Breast Cancer Cells in 3D Culture. JOURNAL OF CELLULAR BIOCHEMISTRY, v. 118, p. 2693-2699, 2017.
  • VILLARREAL W, COLINA-VEGAS L, VISBAL G, CORONA O, CORRÊA RS, ELLENA J, COMINETTI MR, BATISTA AA, NAVARRO M. Copper(I)-Phosphine Polypyridyl Complexes: Synthesis, Characterization, DNA/HSA Binding Study, and Antiproliferative Activity. INORGANIC CHEMISTRY, v. 56, p. 3781-3793, 2017.
  • ULIANA CV, PEVERARI CR, AFONSO AS, COMINETTI ME, FARIA RC. Fully disposable microfluidic electrochemical device for detection of estrogen receptor alpha breast cancer biomarker. BIOSENSORS & BIOELECTRONICS v. 99, p. 156-162, 2017.
  • POPOLIN CP, REIS JPB, BECCENERI AB, GRAMINHA AE, ALMEIDA MAP, CORREA RS, COLINA-VEGAS L, ELLENA J, BATISTA AA, COMINETTI MR. Cytotoxicity and anti-tumor effects of new ruthenium complexes on triple negative breast cancer cells. PLoS One, 2017 Sep 12;12(9):e0183275.
  • OLIVEIRA KM, LUNA-DULCEY L, CORRÊA RS, DEFLON VM,  COMINETTI MR, BATISTA AA. Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis. JOURNAL OF INORGANIC BIOCHEMISTRY 2017 Nov;176:66-76. 
  • POPOLIN C, COMINETTI MR. A review of ruthenium complexes activities on different steps of the metastatic process in breast cancer cells. MINI-REVIEWS IN MEDICINAL CHEMISTRY, v. 17, p. 1-1, 2017.
  • COLINA-VEGAS L, DUTRA JL, VILLARREAL W, NETO JH, COMINETTI MR, PAVAN F, NAVARRO M, BATISTA AA. Ru(II)/clotrimazole/diphenylphosphine/bipyridine complexes: Interaction with DNA, BSA and biological potencial against tumor cell lines and Mycobacterium tuberculosis. Journal of Inorganic Biochemistry, v. 10, p. 30187, 2016. 
  • CORRÊA RS, DA SILVA MM, GRAMINHA AE, MEIRA CS, SANTOS JAF, MOREIRA DRM, SOARES MBP, VON POELHSITZ G, CASTELLANO EE, BLOCH C, COMINETTI MR, BATISTA AA. Ruthenium(II) complexes of 1,3-thiazolidine-2-thione: cytotoxicity against tumor cells and anti-Trypanosoma cruzi activity enhanced upon combination with benznidazole. Journal of Inorganic Biochemistry, v. 163, p. 153-163, 2016.
  • MARTIN ACBM, CARDOSO ACF, SELISTRE-de-ARAUJO HS, COMINETTI MR. Recombinant disintegrin domain of human ADAM9 inhibits migration and invasion of DU145 prostate tumor cells. Cell Adhesion & Migration, p. 1-7, 2015.(download )
  • MANZINE PR, MARCELLO E, BORRONI B, KAMPHUIS W, HOL E, PADOVANI A, NASCIMENTO CMC, VALE FAC, PAVARINI SCI, DILUCA M, COMINETTI MR. ADAM10 gene expression in the blood of Alzheimer's disease patients and mild cognitive impairment subjects. Biomarkers (London. Print), v. 1, p. 1, 2015.
  • SANGI DP, COMINETTI MR, BECCENERI AB, RESENDE FA, VARANDA EA, MONTANARI CA, PAIXAO MW, CORREA AG. Molecular Design, Synthesis and Evaluation of 2,3-Diarylquinoxalines as Estrogen Receptor Ligands. Medicinal Chemistry (Hilversum), v. 11, p. 1-1, 2015. (download )
  • CORREA RS, OLIVEIRA KM, DELOLO FG, ALVAREZ A, MOCELO R, PLUTIN AM,  Cominetti, Marcia R.; CASTELLANO, EDUARDO E.; BATISTA, ALZIR A. Ru(II)-based complexes with N-(acyl)-N?,N?-(disubstituted)thiourea ligands: Synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells. Journal of Inorganic Biochemistry, v. 150, p. 63-71, 2015. (download )
  • MARIA, ROBERTA M.; ALTEI, WANESSA F.; ANDRICOPULO, ADRIANO D.; BECCENERI, AMANDA B.; Cominetti, Márcia R.; VENÂNCIO, TIAGO; COLNAGO, LUIZ A. Characterization of metabolic profile of intact non-tumor and tumor breast cells by HR-MAS NMR spectroscopy. Analytical Biochemistry (Print), v. 1, p. 1, 2015. (download )
  • COLINA-VEGAS, LEGNA; VILLARREAL, WILMER; NAVARRO, MARIBEL; DE OLIVEIRA, CLAYTON RODRIGUES; GRAMINHA, ANGÉLICA E.; MAIA, PEDRO IVO DA S.; DEFLON, VICTOR M.; FERREIRA, ANTONIO G.; COMINETTI, MARCIA REGINA; BATISTA, ALZIR A. Cytotoxicity of Ru(II) piano-stool complexes with chloroquine and chelating ligands against breast and lung tumor cells: Interactions with DNA and BSA. Journal of Inorganic Biochemistry, v. 1, p. 1, 2015. (download )
  • OLIVEIRA, CLAUDIO RICARDO DE; MARQUETI, RITA DE CASSIA; COMINETTI, M. R.; DOUAT, ESTELA SANT'ANA VIEIRA; RIBEIRO, Juliana Uema; PONTES, Carmen Lucia Salla; BORGHI-SILVA, AUDREY; SELISTRE-de-ARAUJO, H. S. Effects of blocking αvβ3 integrin by a recombinant RGD disintegrin on remodeling of wound healing after induction of incisional hernia in rats. Acta Cirúrgica Brasileira (Online), v. 30, p. 134-142, 2015. (download )
  • Plutin AM, Mocelo R, Alvarez A, Castellano EE, Cominetti MR, Graminha A, Ferreira AG, Batista, AA. On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted-N--acyl thioureas. Journal of Inorganic Biochemistry, v. 134, p. 76-82, 2014. (download )
  • Poltronieri J, Becceneri AB, Fuzer AM, Conceição Filho JC, Martin ACBM, Vieira PC, Pouliot N, Cominetti MR. [6]-gingerol as a chemopreventive agent: a review of its activity on different steps of metastatic process. Mini-Reviews in Medicinal Chemistry, v. Feb.18, p. 01, 2014. (download )

  • Patentes
  • COMINETTI, M. R.; MARTIN, A.C.B.M. ; BECCENERI, A. B. ; FUZER, A. M. ; Selistre-de-Araújo, Heloisa S. ; SILVA, J. A. ; Fernandes, J.B. ; MARCONDES, M. C. C. G. ; VIEIRA, P. C. ; POULIOT, N. ; TOMASIN, R. . Composição farmacêutica compreendendo [10]-gingerol e uso como molécula antitumoral e antimetastatica. 2015, Brasil. 
    Patente: Privilégio de Inovação. Número do registro: BR1020150240937, título: "Composição farmacêutica compreendendo [10]-gingerol e uso como molécula antitumoral e antimetastatica" , Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial. Depósito: 18/09/2015
  • BATISTA, A. A. ; COMINETTI, M. R. ; GRAMINHA, A. ; OLIVEIRA, K. M. . Processo de obrenção de compostos de rutênio, compostos de rutênio obtidos e seu uso. 2016, Brasil. Patente: Privilégio de Inovação. Número do registro: BR102016016, título: "Processo de obrenção de compostos de rutênio, compostos de rutênio obtidos e seu uso" , Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial. Depósito: 15/07/2016
  • FARIA, R. C. ; COMINETTI, M. R. ; OLIVEIRA, T. R. ; ERBERELI, C. R. ; MANZINE, PATRICIA REGINA . Dispositivo para detecção do biomarcador ADAM10 para o diagnóstico da doença de Alzheimer, método de aplicação do referido dispositivo, uso do dito dispositivo para diagnóstico da da doença de Alzheimer, método de aplicação de ELISA para diagnóstico da doença de Alzheimer. 2016, Brasil. Patente: Privilégio de Inovação. Número do registro: BR10201601815, título: "Dispositivo para detecção do biomarcador ADAM10 para o diagnóstico da doença de Alzheimer, método de aplicação do referido dispositivo, uso do dito dispositivo para diagnóstico da da doença de Alzheimer, método de aplicação de ELISA para diagnóstico da doença de Alzheimer" , Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial. Depósito: 04/08/2016
  • COMINETTI, M. R.; MARTIN, A.C.B.M. ; TOMASIN, R. ; DULCEY, L. J. L. ; TELES, R. H. G. ; GRAMINHA, A. ; VIEIRA, P. C. ; NAVES, M. A. . Formulação de uso combinado do [10]-gingerol (10G) com a doxorrubicina (DOXO) para o tratamento de câncer de mama triplo negativo (CMTN). 2018, Brasil. Patente: Privilégio de Inovação. Número do registro: BR10201807274, título: "Formulação de uso combinado do [10]-gingerol (10G) com a doxorrubicina (DOXO) para o tratamento de câncer de mama triplo negativo (CMTN)" , Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial. Depósito: 05/11/2018Instituição(ões) financiadora(s): UFSCar.
  • BATISTA, A. A. ; COMINETTI, M. R. ; GRAMINHA, A. ; CASS, Q. B. ; CORREA, R. S. . Processo de obtenção de compostos de rutênio com bioligantes, compostos de rutênio com bioligantes e seu uso. 2014, Brasil. Patente: Privilégio de Inovação. Número do registro: BR102014024476, título: "Processo de obtenção de compostos de rutênio com bioligantes, compostos de rutênio com bioligantes e seu uso" , Instituição de registro: INPI - Instituto Nacional da Propriedade Industrial. Depósito: 30/09/2014
Doenças Estudadas

Câncer

Doença de Alzheimer

Métodos Utilizados

Cultura Celular

Adesão Celular

Apoptose

Ciclo Celular

ELISA

Invasão Celular

Imunocitoquímica

Migração Celular

Modelos de Metástase in vivo

Proliferação Celular

qPCR

Western Blot

 

 

Financiadoras

Fapesp

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